US Government As Represented by the Secretary of the Army

Maurice P La Montagne

Anica Markovac

Arthur B Ash

A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein diosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.

2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials

A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein disclosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.

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Sterling Heights, MI, United States of America

Maurice P La Montagne