Research Institute for Medicine & Chemistry, Inc.

Maurice Murdoch Pechet

Robert H Hesse

Sundara Katugam Srinivasasetty Setty

Michael Gile

Compounds of formula (I) in which: Rrepresents a hydrogen atom or an O-protecting group; Rrepresents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; Rrepresents a methyl group having &#x3b1;- or &#x3b2;-configuration; X represents a Calkylene group or a valence bond; Y represents a carboxaldehyde group or a group of formula &#x2014;C(R)(R)ORwhere Ris as defined above and Rand R, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of Rand Rdoes not exceed three atoms, with the proviso that X is a valence bond when both Rand Rare other than hydrogen; and the dotted line signifies that a double bond may optionally be present at the 16(17)-position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.

2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10) triene derivatives and their biological activity

1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R is hydroxyl or lower alkoxy and R is optionally hydroxylated or lower alkoxylated lower alkynyl or R is C(R ) (R )CH where R is optionally hydroxylated or lower alkoxylated lower alkynyl and R is hydroxyl or lower alkoxy or R and R together represent oxo and R is hydrogen, hydroxyl or lower alkoxy, and R and R represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents.

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Maurice Murdoch Pechet