Centre National De La Recherche Scientifique

Maurice Israël

Jordi Molgo

Sabine De La Porte

Christiane Leprince

Bernard Lesbats

Gérard Baux

Cesar Mattei

Philippe Fossier

Christian Bloy

Emmanuel Chaubourt

The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of beta-naphthoquinone derivatives, and salts thereof, for preventing and/or treating glutamate induced neurological disorders. Additionally, it concerns the use of beta-naphthoquinone derivatives, and salts thereof, for making drugs exerting an inhibitory effect on the release of glutamate.

Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds

A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a nerve tissue preparation and the possible modulating effect of the compound on release of neuromediator by the nerve tissue preparation is determined. Methods of preparing calibrated pieces of mammalian cerebral material and kits for the implementation of the process are also described.

Method for identifying modulating compounds of neurotransmitters

The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises administering to a patient in need thereof a composition containing NO or at least one compound able to release, induce and/or promote NO formation in cells, said administration resulting in augmenting or restoring the production of the fetal isoform of said protein in said patient.

Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof

Growing community of inventors

Bures-sur-Yvette, France

Maurice Israël