Valcare, Inc.

Cryotherapeutics Gmbh

Mvalve Technologies Ltd.

Edwards Lifesciences Corporation

Heart Repair Technologies, Inc.

Micardia Corporation

Endocross Ltd.

Other

Radiance Medical Systems, Inc.

Cardiodex, Ltd.

Maurice Buchbinder

Samuel M Shaolian

David Zarbatany

Ross Tsukashima

John F Krumme

Domenic N Santoianni

Tai D Tieu

Ponaka Pung

Brian C Gray

Julie Logan

Joseph Videll

J Christopher Flaherty

Randell Louis Werneth

Michael Lawrence Reo

Thomas A Afzal

Jeffrey J Christian

Eran Hirszowicz

Daniel Nahon

Gary B Hulme

Valavanur A Subramanian

Hung H Cao

Shay Dubi

Victor S Packham

Ken Perry

Shimon Eckhouse

Shahram Moaddeb

Amit Tubishevitz

Eran Levit

Yiannakis Petrou Yianni

Eran Goldberg

Jeffrey P Dumontelle

Amnon Yadin

Brett A Trauthen

Stewart Maddison Fox

Kenneth E Perry

Peter Kyone Park

Michael Henson

Vadim Bernshtein

Aharon Cohen

Noam Mizrahi

Daniel C Anderson

Jason Tran

Stewart Madison Fox

Paul A Molloy

Ninh H Dang

Paul McCormick

Avi Eftel

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus

A catheter is provided comprising a flexible heat transfer element provided on an outer surface of the catheter. The catheter further comprises a conduit arranged to supply an inflation fluid for inflating the flexible heat transfer element so as to form an inflated balloon, and a plurality of cooling elements arranged to cool the inflation fluid for inflating the balloon. Each cooling element comprises a first tube provided inside a second tube, wherein the first tube is substantially parallel to the second tube. The second tube is configured to receive a flow of a coolant for cooling the cooling element from the first tube.

Balloon catheter

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves via a trans-apical approach to accessing the heart. A guiding sheath may be introduced into a ventricle of the heart through an access site at an apex of the heart. A distal end of the guiding sheath can be positioned retrograde through the target valve. An annuloplasty ring arranged in a compressed delivery geometry is advanced through the guiding sheath and into a distal portion of the guiding sheath positioned within the atrium of the heart. The distal end of the guiding sheath is retracted, thereby exposing the annuloplasty ring. The annuloplasty ring may be expanded from the delivery geometry to an operable geometry. Anchors on the annuloplasty ring may be deployed to press into and engage tissue of the annulus of the target valve.

Percutaneous transcatheter repair of heart valves via trans-apical access

The present invention provides an intracardiac device suitable for minimally-invasive delivery, wherein said device comprises a device body and one more stabilizing elements attached to said device body. The stabilizing elements may be selected from the group consisting of: stabilizing wings having at least one portion with a thickness greater than that of the device body, wings comprising one or more auxiliary support arms, wings having a metal wire coil wound around them, wings having a leaf spring attached thereto, polymer-coated stabilizing wings, and mechanical stabilization elements comprising a rotatable jaw-like structure.

Intracardiac devices comprising stabilizing elements having improved fatigue resistance

Cardiac valve supports and their methods of use.

Cardiac valve support structure

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.

Percutaneous transcatheter repair of heart valves

There is provided a method of supplying cryoenergy to a plaque within a blood vessel. The method comprises expanding an expandable membrane of a catheter apparatus with a pressure of less than 5 ATM (507 kPa), the catheter apparatus having been placed in thermal contact with the plaque within the blood vessel. The method also comprises establishing a temperature of between +15&#xb0; C. (288K) and &#x2212;35&#xb0; C. (238K) at an interface of the expandable membrane and the blood vessel. A system and catheter apparatus are also provided.

Plaque stabilization using cryoenergy

Plaque stabilisation using cryoenergy

Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.

Adjustable annuloplasty ring with subcutaneous activation port

The present invention is directed to a method of securing suture within a patient. The method comprises advancing suture material into the patient, passing a portion of the suture material through tissue of the patient, and advancing a fastener catheter and a suture fastener along the suture material. The fastener catheter includes a catheter main body and a handle. The suture fastener has a generally cylindrical body formed of a shape memory material and a suture fastener inner lumen. The suture fastener has at least one engagement tab biased to extend at least partially into the suture fastener inner lumen to engage against and secure one or more lines of suture passing through the suture fastener.

Mitral valve repair system and method for use

A balloon catheter system for the intraluminal advancement of conventional guidewires beyond partially or fully occluded or stenosed lesions in body passages, such as CTOs in the vasculature, is provided. Balloons are provided. In certain embodiments of the invention, a balloon having relatively thickened proximal tapers is provided. In certain embodiments of the invention, balloons having a tapered midsection are provided. The balloons are preferably useful with crossing balloon catheter systems. In certain embodiments of the invention, the balloons preferably reduce or minimize trauma to the vascular wall or wall of other body passage in which it is used.

Balloons and balloon catheter systems for treating vascular occlusions

Growing community of inventors

La Jolla, CA, United States of America

Maurice Buchbinder