Chemocentryx, Inc.

Leland Stanford Junior University

Maureen Howard

Thomas J Schall

Jennifer M Burns

Zhenhua Miao

Brett Anthony Premack

Zheng Wei

Bretton Summers

Irving L Weissman

Ravindra Majeti

Jie Liu

Jens-Peter Volkmer

Stephen Willingham

Susan Sweeney Prohaska

Anne Kathrin Volkmer

Dale John Talbot

Robert Berahovich

Robert Berkovitz

Anne K Volkmer

Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Methods for achieving therapeutically effective doses of anti-CD47 agents

Methods for treating myeloma by achieving therapeutically effective doses of anti-CD47 antibody

The inventors have discovered that a CK&#x3b2;8-1 truncation variant, CK&#x3b2;8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CK&#x3b2;8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CK&#x3b2;8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CK&#x3b2;8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.

Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof

Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.

Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors

Antibodies that bind CCX-CKR2 are described.

Compositions for detecting and treating diseases and conditions related to chemokine receptors

Antibodies that bind to CCX-CKR2 and methods of their use are provided.

Antibodies that bind CCX-CKR2

The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.

The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.

This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for, among other things, vaccine formulation for therapeutic and prophylactic vaccination (immunization) and for production of useful antibodies (e.g., monoclonal antibodies for therapeutic or diagnostic use).

Growing community of inventors

Los Altos, CA, United States of America

Maureen Howard