Ginkgo Bioworks, Inc.

Novogy, Inc.

Woundchek Laboratories (us), Inc.

Maureen Hamilton

Arthur J Shaw, Iv

Mitchell C Sanders

Johannes Pieter Van Dijken

Gerard J Colpas

Elena E Brevnova

Vasiliki Tsakraklides

Emily H Greenhagen

Jonathan Friedlander

Annapurna Kamineni

Adrian Lowe

William G LaTouf

Andrew L Consiglio

Kyle M MacEwen

Disclosed are transformed cells and related nucleotide and protein sequences, and fermentation compositions and methods, all of which are related to providing selective advantage in fermentation. For example, a selective advantage results from transformation of a cell with a nucleic acid that allows a transformed cell to metabolize one or more nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell cannot metabolize, and from fermentation of the transformed cell using one or more feedstocks, such as fractioned grain, which are depleted in or free of conventional nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell can metabolize. Also disclosed are methods for improved oxygen transfer in an aerobic or microaerobic fermentation.

Selective advantage in fermentation

Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.

Enhanced production of core lipids in oleaginous yeasts

Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.

Method for detecting microorganisms

Growing community of inventors

Littleton, MA, United States of America

Maureen Hamilton