Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

Leonard, Kristi A.

Maud J Urbanski

David A Kummer

Aihua Wang

Hariharan Venkatesan

James Patrick Edwards

Ronald L Wolin

Kevin Douglas Kreutter

Kristi A Leonard

Rachel T Nishimura

Craig R Woods

Umar Maharoof

Kent Barbay

Philip J Rybczynski

Xiaoyan Zhang

Xiaohua Xue

Maxwell David Cummings

Anne Fourie

Mona Patel

Mary Pat Beavers

Steven D Goldberg

Virginia M Tanis

Roxanne Zeck

Kelly J McClure

Joseph Dudash

Yongzheng Zhang

Amy Xiang

Christian Gege

Keith T Demarest

Christoph Steeneck

Olaf Kinzel

William Moore Jones

Gerald Kleymann

Thomas Hoffmann

Robert H K Chen

Taraneh Mirzadegan

Joan M Pierce

Hiayan Bian

Min (Amy) Xiang

Joseph W Gunnet, Jr

Kelly Ganamet

Kelly Mcclure

Joan Pierce

Kelly Lynn Ganamet

Anne M Fourie

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Alkyl linked quinolinyl modulators of ROR&#x3b3;t

Phenyl linked quinolinyl modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I. wherein: The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Quinolinyl modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I. wherein:R, R, R, R, A, A, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Amide substituted thiazoles as modulators of RORyt

The present invention comprises compounds of Formula I.  The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Heteroaryl linked quinolinyl modulators of RORgammat

Heteroaryl linked quinolinyl modulators of ROR&#x3b3;t

Methylene linked quinolinyl modulators of ROR&#x3b3;t

Secondary alcohol quinolinyl modulators of ROR&#x3b3;t

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.

Substituted dihydroisoindolones as allosteric modulators of glucokinase

Substituted pyrrolones as allosteric modulators of glucokinase

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Belle Mead, NJ, United States of America

Maud J Urbanski