Boehringer Ingelheim Gmbh

Heinrich Mack Nachf

Pfizer Corporation

Matyas Leitold

Gunther Schmidt

Peter Stoss

Gunther Engelhardt

Johannes Keck

Gerd Kruger

Sigfrid Puschmann

Oswald Tauber

Helmut Pieper

Rudolf Hurnaus

Wolfgang Grell

Robert Sauter

Gerhart Griss

Bernhard Eisele

Klaus-Reinhold Noll

Nikolaus Kaubisch

Rodney Yeates

Novel aminopropanol derivatives of 1,4:3,6-dianhydro-hexitol nitrates of the general formula I ##STR1## in which X has the meaning given in the specification, processes for their preparation and their use in preventing and treating angina pectoris, systemic hypertension and pulmonary hypertension in mammals.

Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates,

Oxime ethers of 2,6-dioxabicyclo[3.3.0]octanones of the formula I ##STR1## have pharmacological activity and are especially applicable as drugs for the prophylaxis and therapy of cardiac and circulatory diseases.

Oxime ethers of 2,6-dioxabicyclo(3.3.0)octanones, and compositions and

Dianhydrohexites of the formula ##STR1## wherein R.sup.1 is hydrogen or benzyl, R.sub.2 is alkyl or omega-theophyllin-7-yl-alkyl, and R.sup.1 and R.sub.2 together with the nitrogen atom to which they are attached form a bicyclic group and R.sup.3 is hydrogen, acyl, pyridylcarbonyl, nitro or a hydroxylamino group, are formed by an analogous method and used as pharmaceuticals in the treatment of heart and circulatory diseases.

Dianhydrohexite derivatives, and their use as pharmaceuticals

The present invention relates to new acyl derivatives of 1,4:3,6-dianhydrohexitols, processes for their preparation and drugs containing the same. The new compounds have a cardiovascular effect and can be used as antihypertensive agents, as peripheral and central vasodilators and as coronary therapeutic agents.

Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols

Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.

Antiphlogistic pharmaceutical compositions and method of use

Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 3 to 12 carbon atoms; unsaturated aliphatic hydrocarbyl of 3 to 20 carbon atoms comprising 1 to 3 double bonds and/or one triple bond; phenyl(alkyl of 2 to 4 carbon atoms); methylenedioxybenzyl; chlorobenzyl; indan-5-ylmethyl; indan-3-ylmethyl; phenyl(alkenyl of 2 to 4 carbon atoms); cycloalkyl of 5 to 7 carbon atoms; (cycloalkyl of 3 to 10 carbon atoms)methyl; (methylcycloalkyl of 4 to 11 carbon atoms)methyl; morpholino(alkyl of 2 to 3 carbon atoms); pyrrolidino(alkyl of 2 to 3 carbon atoms); piperidino (alkyl of 2 to 3 carbon atoms); 4-methylpiperazino(alkyl of 2 to 3 carbon atoms); or, when R.sub.3 and/or R.sub.4 are methyl or ethyl, also methyl or ethyl;

11-(Piperazino-acetyl)-5,11-di

Novel 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-ones of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, straight and branched chain, mono and poly unsaturated aliphatic hydrocarbon of 3 to 20 carbon atoms, phenyl alkyl of 1 to 4 alkyl carbon atoms and cinnamyl, R.sub.2 is selected from the group consisting of hydrogen, methyl and ethyl and A is straight or branched chain alkylene of 2 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having ulcer inhibiting and secretion inhibiting activity and a novel process for their preparation.

Novel 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-ones

Compounds of the formula ##STR1## wherein A is alkylene of 1 to 5 carbon atoms;

II-Aminoacyl-5,11-dihydro-6H-pyrido(2,3-B) (1,4)benzodiazepin-6-ones and

Antiphlogistic pharmaceutical composition and method of use

Compounds of the formula ##STR1## wherein X and R.sub.1 are each chlorine or bromine;

2- OR 4-Hydroxy-3,5-dihalo-benzylamines and salts thereof

Compounds of the formula ##STR1## wherein X is chlorine or bromine;

Halo-substituted hydroxybenzyl-amines as secretolytic agents

Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,

Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their

Biphenyloxy derivatives and antihyperlipidemic use

Pharmaceutical compositions containing as an active ingredient an N-(hydroxy-cyclohexyl)-benzylamine of the formula ##SPC1## Wherein R.sub.1 is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as anti-ulcerogenics.

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Biberach, Germany

Matyas Leitold