Sanofi-Aventis

Agro-Chemie

Mátyás Aradi

Istvan Szekely

Bela Bertok

Zsolt Dombrády

Zsolt Párkányi

Attila Supic

Geza Arvai

Erzsebet Szalay

Zsuzsanna Kuruczne Ribai

Antal Gajáry

József Ugrics

Sándor Viktor Szabó

Ferenc Kovács

Andrea Major

Ferenc Bakos

Erika Máténé Török

László Schultz

István Gyöngyösi

Erzsébet Szalay

József Zsiga

The process according to the invention relates to the preparation of 2-chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II). Compounds of formula (I) and (II) are intermediates of several pharmaceutically active ingredients.

Chloromethylation of thiophene

The subject of our invention is the process for the preparation of the 1-(3,4-dimethoxyphenyl)ethanol of formula (I), by the reduction of 3,4-dimethoxyacetophenone of formula (II), characterized in that the carbonyl group of the 3,4-dimethoxyacetophenone of formula (II) is reduced by 1 mol of hydrogen under the conditions of catalytic hydrogenation.

Process for the preparation of 1-(3,4-dimethoxyphenyl)ethanol

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Budapest, Hungary

Mátyás Aradi