Ecole Polytechnique Federale De Lausanne

Richard Wolf Gmbh

Vestergaard Frandsen Sa

Matthieu Zellweger

Mikkel Vestergaard Frandsen

Georges Wagnieres

Norbert Lange

Hubert Van Den Bergh

Ulf Zanger

Patrice Jichlinski

Pavel Kucera

Alexandre Marti

Huyen Thanh Hoang

Andre Studzinski

Nicolas Chauvin

Sebastien Gouin

The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case diagnosis, by detection of fluorescent protoporphyrin IX (Pp1X). The E-ALA concentration in the solution is less than 1% and ranges between 0.01% and 0.5%. The low E-ALA concentration in the solution increases Pp1X synthesis and homogenises its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells.

Solution for diagnosing or treating tissue pathologies

The diagnosis apparatus according to the invention for the picture providing recording of fluorescing biological tissue by way of an endoscope contains a stimulation light source which beams spectral components suitable for fluorescence stimulation into the tissue through the endoscope. The fluorescent light reflected by the tissue reaches through the endoscope optics into a head piece where it is split into a green, and spacially separated from this, a red spectral component and falls each on one half of a CCD solid body of a highly sensitive black and white camera. In an electronic and processor component the video signals allocated to the green and to the red spectral component are processed into two separate processing channels in a manner such that the separately processed green-red video signals are simultaneously inputted to a color video monitor and here may be superimposed to a red-green monitor picture, which may show changes of tissue indicating disease, for example dysplasia, carcinomas in situ etc., in all organs which are endoscopically accessible.

Diagnosis apparatus for the picture providing recording of fluorescing

Growing community of inventors

Lausanne, Switzerland

Matthieu Zellweger