Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur

Institut National De La Recherche Agronomique

Enterome

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Matthieu Pichaud

Pierre Rimbaud

Stanislav Ehrlich

This invention is related to the area of characterization of inflammation in relation with the gut microbiota, in metabolic and autoimmune disorders. In particular, it relates to the identification of gene signatures which can be used as a marker predictive of inflammation associated diseases, such as liver-related metabolic disorders, in particular to the evolution of benign steatosis towards its most severe forms (steatohepatitis and cirrhosis) or autoimmune disorders, in particular inflammatory bowel diseases (Crohn's and Ulcerative Colitis). These gene signatures can therefore be used as a means of diagnosis, prognosis, stratification for drug studies, for monitoring patient and for assigning an appropriate treatment.

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Paris, France

Matthieu Pichaud