Columbia University

Matthieu Jean Michel Rueegg

Samuel K Sia

Nalin Tejavibulya

At least one microneedle comprises a hydrogel material that includes a substance that fluoresces when the substance interacts with an analyte. A magnitude of the fluorescence varies as a function of the concentration of the analyte. During use, the hydrogel material is illuminated with illumination light in a first wavelength range while the hydrogel material interfaces with the dermal interstitial fluid layer of a subject, and a photosensor generates an output that corresponds to an amount of light received in a second wavelength range.

Devices and systems for optically determining a concentration of an analyte in a living subject using hydrogel-based, fluorescent microneedles and methods of manufacture thereof

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Saint-Sulpice, Switzerland

Matthieu Jean Michel Rueegg