Children's National Medical Center

Matthieu F Dumont

Raymond W Sze

Rohan Fernandes

Laurie S Conklin

Hilary A Hoffman

Jyoti K Jaiswal

Catherine M Bollard

Anthony Sandler

Conrad Russell Y Cruz

Carolyn T Cochenour

Brian K Reilly

Peng (Patrick) Cheng

Juliana Cano-mejia

Rachel Burga

Elizabeth E Sweeney

Combination treatment with Prussian blue nanoparticles and at least one immunotherapeutic treatment. Stable, functionalized Prussian blue nanoparticles, including those with enhanced stability under alkaline conditions, and methods of cancer, neoplasm, and tumor treatment using them, including photothermal treatment and combination immunotherapeutic treatments.

Functionalized Prussian blue nanoparticles, combination Prussian blue nanoparticle-based nano-immunotherapy and applications thereof

The purpose of the 'Dissolvable on-command Implant' is to act as a pressure equalizer tube in the eardrum, which has the unique characteristic that the tube can be dissolved with a specially formulated drop solution on-command. This tube can have various shapes and sizes, although the tube is usually a cylindrical tube with a hollow center, which maintains a ventilatory port for the middle ear space. With this design, the ear tube promotes drainage of middle ear fluid, lets air enter the middle ear, and allows for instillation of antibiotic drops.

Dissolvable on-command implant

The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.

Prussian blue-inspired constructs for multimodal imaging and therapy

Growing community of inventors

Tallahassee, FL, United States of America

Matthieu F Dumont