Bayer Pharma Aktiengesellschaft

Matthias Werner

Karl-Heinz Schlemmer

Joachim Schuhmacher

Susanne Röhrig

Johannes Köbberling

Michael Sperzel

Nils Burkhardt

Christian Stegmann

Manuel Ellermann

Tom Kinzel

Maria Köllnberger

Kristin Beyer

Jorma Haßfeld

Yolanda Cancho Grande

Yolanda Cancho-Grande

Jorma Haβfeld

Susanne Rohrig

Jorma Hassfeld

Jan Stampfuß

Gaelle Valot

Willem Jan Hengeveld

Jörg Heiermann

Imke Meyer

Maria Kollnberger

Johannes Kobberling

The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use

The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

Piperidinylpyrazolopyrimidinones and their use

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Wuppertal, Germany

Matthias Werner