Innate Pharma S.a.s.

Novo Nordisk-a/s Novo Alle

University of Genoa

Matthias Thorolfsson

Alessandro Moretta

Pascale Andre

Peter Andreas Nicolai Reumert Wagtmann

Kristian Kjaergaard

Francois Romagne

Stefan Zahn

Anders Svensson

Mariella Della Chiesa

Ivan Svendsen

Laurent Gauthier

Soren Berg Padkjaer

Michael Wilken

Petrus Johannes Loius Spee

Milchael Wilken

Soren Berg Padkaer

Pieter Johannes Louis Spee

Laurant Gauthier

Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.

Human anti-KIR antibodies

Nucleic acids encoding human anti-kir antibodies

Growing community of inventors

Charlottenland, Denmark

Matthias Thorolfsson