UniversitÄt Zu Koln

Protagen Ag

Oncimmune Germany Gmbh

Matthias Schneider

Angelika Lüking

Petra Budde

Andreas R Klatt

Gabriele Hermes

Johannes Ruthard

Benedikt Ostendorf

Dieter Zucht

Georg Pongratz

Angelika LÜKING

Methods, kits, and active ingredients for diagnosing or treating arthritis or a degenerative disease of the skeletal system, or for selection of subjects for therapy. The methods for diagnosing arthritis involve the detection of an autoantibody, which is associated with arthritis, or excluding the presence of an autoantibody against collagen II. The methods for diagnosing a degenerative disease of the skeletal system, involve the detection of an autoantibody against thrombospondin-4 or COMP. The kits contain a detection agent for an autoantibody and can be used for diagnosing arthritis or a degenerative disease of the skeletal system. The active ingredient can be used for treating or preventing autoimmune-associated arthritis.

Detection of autoantibodies for diagnosing degenerative diseases of the skeletal system

The present invention relates to methods for identifying markers for systemic sclerosis (also referred to as scleroderma; SSc) and the markers identified with the aid of this method, which can differentiate between SSc and other autoimmune diseases on the one hand and between different SSc subgroups on the other hand. The invention also relates to panels, diagnostic devices, and test kits which comprise these markers, and also to the use and application thereof, for example for the diagnosis, prognosis and therapy control of SSc. The invention also relates to methods for screening and for validating active substances for use in SSc subgroups.

Marker sequences for the diagnosis and stratification of systemic sclerosis patients

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Düsseldorf, Germany

Matthias Schneider