Schering Aktiengesellschaft

Inhale Therapeutic Systems, Inc.

Actipac Biosystems Gmbh

Matthias Rothe

Celal Albayrak

Joachim Siegert

Georg R&ouml;ssling

Georg Ro/ Ssling

Georg R{haeck Over (o)}ssling

The invention relates to a process for the production of gaseous microparticles for ultrasonic diagnosis, whose wall material is built up from polyesters of &agr;-, &bgr;- or &ggr;- hydroxycarboxylic acids, particles that are produced according to this process, as well as their use in medical diagnosis.

Process for producing polymeric microparticles, microparticles produced by said process and the use of such particles in medical diagnostics

The invention relates to gaseous microparticles for ultrasonic diagnosis, whose wall material is built up from block copolymers of polyesters of &agr;-, &bgr;- or &ggr;-hydroxycarboxylic acids with linear or star-shaped polyethylene glycols and optionally liquid crystals or whose wall material is built up from polyesters of &agr;-, &bgr;- or &ggr;-hydroxycarboxylic acids and liquid crystals, media that contain these particles for ultrasonic diagnosis, as well as a process for the production of the media and particles.

Gaseous microparticles for ultrasonic diagnosis and process for their production

Microparticles comprising biodegradable polymers, characterized in that they are synthesized from polymerizable aldehydes, which optionally contain additives and/or crosslinkers capable of copolymerization, optionally surfactants or surfactant mixtures, gases and/or highly volatile liquids in free or bound form, coupling agents, optionally biomolecules or macromolecules bound by these coupling agents as well as optionally diagnostically or therapeutically effective components, are suitable as ultrasonic contrast media.

Contrast media synthesized from polyaldehydes

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Berlin, Germany

Matthias Rothe