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Diacoating Gmbh

Matthias Rainer

Douglas T Gjerde

Guenther Bonn

Günther Bonn

Christian Wolfgang Huck

Günther Stecher

Detlef Steinmüller

Muhammed Najam-Ul-Haq

Frank Rudolf Kloss

Doris Steinmüller-Nethl

Robert Gassner

The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for many types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics.

Isolation of phosphoproteins, glycoproteins and fragments thereof

A base body contains a substrate that is at least partially coated with a carbon-containing layer. The carbon-containing layer is at least partially functionalized with a molecule that is bound directly or via at least one linker or functional group to the carbon-containing layer. The base body, which has a functionalized carbon-containing surface, is capable of influencing biological processes during a corresponding functionalization.

Biological surfaces

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Grinzens, Austria

Matthias Rainer