Acucela Inc.

Clear Image Technology, LLC

Matthias Pfister

Ryo Kubota

Philip M Buscemi

Stefan Troller

Urban Schnell

Stephan Wyder

Lukas Scheibler

Karim Haroud

Christian Oggenfuss

Alexander Holzer

Cyril Stoller

Michel Saint-Ghislain

Amitava Gupta

Jean-Christophe Roulet

Jacob Schubert

Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

Miniaturized mobile, low cost optical coherence tomography system for home based ophthalmic applications

An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

Scan pattern and signal processing for optical coherence tomography

An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

System and method for optical coherence tomography a-scan decurving

A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.

Artificial intelligence for evaluation of optical coherence tomography images

An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser ('VCSEL').

Axial length measurement monitor

A medical imaging system, is formed of a lighting module, preferably using a single LED. The LED illuminates a reflection chamber, located to receive light from the LED, said reflection chamber terminating in a fiber interfacing surface. An optical fiber, connects to the fiber interfacing surface, and receives light therefrom when said LED is energized. The optical fiber has a first surface connected to the fiber interfacing surface, and has a second surface at an opposite end of the optical fiber from the first surface. A light guide, has a first end, optically coupled to the second end of said optical fiber, and the light guide directs light from the first end into a cone shaped surface at a second end, that directs light away from a center of the cone shaped surface into a hollow cylindrical shape of light, creating an illumination by the light at a distal end of the hollow cylindrical shape opposite the first end. A camera, mounted inside the light guide, within an inside of the cone shaped surface images the area illuminated by the light guide.

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Liebefeld-Bern, Switzerland

Matthias Pfister