Bayer Aktiengesellschaft

Matthias M uller-Gliemann

Stefan Wohlfeil

Martin Beuck

Ulrich E M Uller

Johannes-Peter Stasch

Andreas Knorr

Peter Fey

Stanislav Kazda

Rudolf H Hanko

Siegfried Zaiss

J Urgen Dressel

Thomas Kr Amer

Walter H Ubsch

Dirk Denzer

Ozkan Yalkinoglu

Hilmar Bischoff

Walter Hubsch

Christoph Gerdes

Thomas Kramer

James J Elting

Claudia Hirth-Dietrich

Stefan Lohmer

Anke Domdey-Bette

Rudi Gr Utzmann

Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating. The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.

Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives

Substituted indole derivatives are prepared by reacting appropriate carboxylic acids, if appropriate in the presence of auxiliaries, with appropriate amines. The substituted indole derivatives are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and restenosis.

Substituted indole derivatives

Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.

Substituted biphenylpyridones

Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,

Trisubstituted biphenyls

The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis.

Substituted monopyridylmethyl derivatives

Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments.

Phenylglycinamides of heterocyclically substitued phenylacetic acid

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Matthias M uller-Gliemann