Merckle Gmbh

Other

Matthias Lehr

Gerd Dannhardt

Joachim Ludwig

Ludwig Steindl

The invention relates to novel heteroaryl substituted acetone derivatives which inhibit the enzyme phospholipase A, pharmaceutical preparations containing these compounds and a method of producing these compounds.

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The invention provides novel antiinflammatory and analgesic agents of the formulae

Acylpyrroledicarboxylic acids and acylindoledicarboxylic acids and their derivatives as inhibitors of cytosolic phospholipase A2

The invention concerns substituted pyrrole compounds and their pharmaceutical applications. The compounds of the invention are potent inhibitors of lipoxygenase and cyclo-oxygenase and therefore are suitable to treat the set of rheumatic illnesses and to prevent allergically induced ailments. The compounds have the general formula: ##STR1## where R.sup.1 denotes a C.sub.1 -C.sub.12 alkyl group, R.sup.2 denotes a hydrogen atom or a C.sub.1 -C.sub.12 alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom and the nitrogen atom to which they are bound form a ring of 5 to 8 links which may contain a sulfur heteroatom or a carbonyl group and may be substituted with one or two C.sub.1 -C.sub.4 alkyl groups,

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Havixbeck, Germany

Matthias Lehr