Dow Global Technolgoies LLC

Other

Nutrition & Biosciences USA 1, LLC

Dow Wolff Cellulosics Gmbh Co

Ddp Specialty Electronic Materials Us, LLC

Matthias Knarr

Roland Adden

Meinolf Brackhagen

Oliver Petermann

Robert L Sammler

Roland Bayer

Jin Zhao

Britta Huebner-Keese

Robert L Schmitt

Nicholas S Grasman

Steven J Guillaudeu

Neal J Fetner

David L Malotky

Susan L Jordan

Matthias Sprehe

True L Rogers

Puspendu Deo

Robert B Appell

Alexandra Hild

Sonja Scharlemann

Carol E Mohler

Rene Kiesewetter

Joerg Neubauer

Kathryn Brown

Tirtha Chatterjee

Jonathan D Moore

Grit Grote

Britta Huebner

Michael J Devon

Roja Ergun

Jaime L Curtis-Fisk

Anne Adden

William H Anderson

Franz Mayer

Carol Elaine Mohler

Johnathan D Moore

An aqueous composition which is useful for producing coatings and capsule shells comprises a) dispersed particles of an esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a divalent hydrocarbon group and A is hydrogen or a cation, and the total degree of ester substitution is more than 0.70, and b) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH is not more than 0.4, II) the total degree of ester substitution is from 0.03 to 0.70, and III) the esterified cellulose ether b) has a solubility in water of at least 2.0 weight percent at 2&#xb0; C.

Aqueous composition comprising dispersed esterified cellulose ether

A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa&#xb7;s, measured as a 2 wt.-% solution in water at 20&#xb0; C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa&#xb7;s and optionally one or more adjuvants.

Composition comprising an organic liquid diluent and a cellulose ether of very low viscosity

An esterified cellulose comprising aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.03 to 0.38, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20&#xb0; C.

Gelling esterified cellulose ethers

A liquid composition which comprises an organic liquid diluent and a hydroxyalkyl methylcellulose which has a certain distribution of substituted hydroxyalkoxyl groups and unsubstituted hydroxyalkoxyl groups is stable over an extended time period. In the hydroxyalkyl methylcellulose hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.

Composition comprising an organic liquid diluent and a specific hydroxyalkyl methylcellulose

Provided is a method of making methylcellulose-type ether in powder form, said method comprising

Cellulose ether powders

Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21&#xb0; C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.

Esterified cellulose ethers of low acetone-insoluble content

A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.

Process for producing dispersion of esterified cellulose ether

An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.

Dispersion comprising an esterified cellulose ether

1. An esterified cellulose ether which i) comprises groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH or a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight Mof up to 70,000 Dalton, iii) has a degree of neutralization of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2&#xb0; C., is useful for preparing enteric capsules.

Water-soluble esterified cellulose ethers

An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C.

Water-soluble esterified cellulose ethers having a low degree of neutralization

A new water-based inorganic binder composition includes inorganic binder, cellulose ether and microcrystalline cellulose. A new additive for water-based inorganic binder compositions includes cellulose ether and microcrystalline cellulose. A method for improving the properties of water-based inorganic binder compositions includes blending a combination of cellulose ether and microcrystalline cellulose in the water-based binder composition.

Cellulose ether and microcrystalline cellulose in inorganic binder compositions

A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Composition for application to a nasal mucosa comprising a methylcellulose

An aqueous solution comprising (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, is produced by i) mixing the methylcellulose with an aqueous liquid comprising one or more mono-, di- and/or oligosaccharides at a shear rate of at least 1000 sor ii) mixing one or more mono-, di- and/or oligosaccharides with the methylcellulose and/or an aqueous liquid before, simultaneously with or after mixing the methylcellulose with the aqueous liquid at a shear rate of at least 1000 s.

Process for preparing an aqueous solution of saccharides and methylcellulose

Cellulose ethers are described herein which are useful in food compositions. In these cellulose ethers the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the cellulose ether has a DS(methyl) of from 1.65 to 2.20, an MS(hydroxyalkyl) of from 0.10 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [s23/s26&#x2212;0.2*MS(hydroxyalkyl)] is 0.35 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Growing community of inventors

Nienburg/Weser, Germany

Matthias Knarr