Kuros Biosciences Ag

Cytos Biotechnology Ag

Matthias Kinzler

Karl Proba

Frank Hennecke

Chi Lan Le

Philippe Saudan

Isabelle Lacan

Jennifer Erickson

The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before. The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof. The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%.

Oligonucleotides packaged into virus-like particles of RNA bacteriophages

Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages

Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages

Process for producing aggregated oligonucleotides

Growing community of inventors

Zurich, Switzerland

Matthias Kinzler