Merck Patent Gmbh

Matthias Joehnck

Romas Skudas

Bianca Edelmann

Eckhard Sabrowskii

Mikhail Kozlov

Matthew T Stone

Kevin Galipeau

Daniel Scheid

Klaus Adrian

Annika Aldinger

Achim Schwaemmle

Dirk Mueller

Marc Mazur

Simon Braun

Eckhard Sabrowski

The present invention refers to a method for the separation of peptide aggregates and fragments from solutions containing target peptide.

Target molecule capture from crude solutions

The present invention refers to a method for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies.

Robust antibody purification

The present invention relates to the purification of target molecules like immunoglobulins from plasma. The use of a certain type of ion exchanger based on a crosslinked polyvinylether results in especially high yields of the target molecule.

Purification of immunoglobulins from plasma

The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.

Ce(IV)-initiated graft polymerisation on polymers containing no hydroxyl groups

The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerization from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.

Hydrophilic crosslinked polymer

The present invention relates to a process for the production of the largest possible spherical, monodisperse polyvinylpyrrolidone (PVP) seed particles in the micron range by dispersion polymerisation. The particles obtained in this way represent novel starting materials for the production of macroporous polymer particles, which can in turn be employed in preparative and analytical chromatography for protein preparation. They can also be employed as base material for further reactions. The novel process for the polymerisation of N-vinylpyrrolidone, which is inexpensive to carry out, gives particles having optimised quantities, such as monodispersity, sphericity and particle diameter, which can be employed in further reactions and have advantageous, in particular improved, properties for use in chromatographic separation methods.

Method for producing hydrophilic poly-N-vinylpyrrolidone and use thereof

The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerisation from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.

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Darmstadt, Germany

Matthias Joehnck