Veb Jenapharm

Matthias Hilliger

Wolf Junne

Harald Bocker

Hans-Helmut Grosse

Heinz Thrum

Ingeborg Heller

Wolfgang Forberg

Hans D Pohl

Heinz Fricke

Gunter Plonka

Hellmut Linde

Jorg Schneider

Klaus-Dieter Menzel

Peter-Jurger Muller

Friedrich Bergter

Ernst-Joachim Bormann

Udo Grafe

Michael Menner

A process is disclosed for the fermentative production of the ergotropically effective antibiotic nourseothricin, with which, using different carbohydrate sources and suitable inorganic and organic nitrogen sources as well as different mineral salts, with or without addition of stock substances of the respiratory chain or the intracellular amino acid transport, and through influencing the phosphate substance exchange and avoidance of further limitations with regulated acidity conditions, high concentrations of this antibiotic are cultivated in the culture solution. The recovery of the active substance in the culture solution follows either by chromatographic techniques in the form of salts or through addition of a physiologically compatible adsorbent as mycelium-containing nourseothricin-adsorbate, which preferably can be added to the dosaging of mixed feed agents.

Process for the production of nourseothricine and its adsorbate

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Jena, Germany

Matthias Hilliger