University of California

The United States Government As Represented by the Department of Veterans Affairs

The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone

Matthias Hebrok

Holger Andreas Russ

Gopika G Nair

Sheng Ding

Saiyong Zhu

Jeffrey A Bluestone

Qizhi Tang

Mark Stuart Anderson

Wenhan Chang

Casey Ward

Peter Stock

Gaetano Faleo

Audrey Parent

Eleonora De Klerk

Thuy Vo

Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.

Preservation of pancreatic islet grafts in the extrahepatic space

Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.

Methods and compositions for producing pancreatic beta cells

Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into the mature beta cells of enriched beta clusters, wherein the beta cells rapidly and reliably secrete insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals. These cells can also be used for drug screening purposes to identify factors/chemicals capable of increasing beta cell functions, proliferation, survival, and resistance to immune assault.

Production of fully functional mature beta cells from human pancreatic progenitors

Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals.

Controlled induction of human pancreatic progenitors produces functional beta-like cells

Methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro are provided. Compositions and systems of cell populations of TEP cells as well as cells formed during different stages of differentiation of PS cells into TEP cells are also disclosed. The methods, isolated in vitro cell populations, compositions, and systems disclosed provide functional TEP cells that mature into thymic epithelial cells in vivo.

Generation of thymic epithelial progenitor cells in vitro

Growing community of inventors

Belmont, CA, United States of America

Matthias Hebrok