Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Other

Roche Diabetes Care, Inc.

Roche Diagnostics International Ag

Matthias Essenpreis

Sebastiaan La Bastide

Martin Gerber

Michael Schoemaker

Wolfgang Petrich

Harvey B Buck, Jr

Nicole Bernini

Derek Brandt

Joel Jeckelmann

Gunnar Meyer Olden

Theodor Koschinsky

Sascha Heckermann

Sybille Fankhauser

Ulrich Haueter

Stefan Weinert

Nigel A Surridge

Tejal Ashwin Desai

Arnulf Staib

Mauro Ferrari

Christoph Cronrath

Kelly Heaton

Derek James Hansford

Remmert Laan

Hans-Martin Kloetzer

Michael Shoemaker

Dirk Bocker

Stephen Nickell

Michael V Hansen

An ambulatory medical device and a method of communication between medical devices are disclosed. In one embodiment, the medical device includes a module for communication with at least a second medical device wherein the module for communication is adapted to be activated by a value of a physiological parameter of an animal. In one embodiment, the method of the present invention involves a first medical device and at least a second medical device wherein the communication between said medical devices is activated by a value of a physiological parameter of an animal.

Ambulatory medical device and method for communication between medical devices

A method for diabetes care, the method (which also may be referred to as, involve or incorporate at least one of a tool, device or program) allowing for the characterization of the relevance of errors of parameters affecting glucose concentration on a postprandial glucose concentration outcome for a person with diabetes mellitusm, wherein the method involves at least one of sensing, determining, calculating, predicting, describing and communicating the effects of potential errors of parameters affecting glucose concentration on postprandial glucose concentration values within a clinically relevant glucose range.

System, tools, devices and a program for diabetes care

A collection device with a selective display of test results and method thereof are disclosed. A structured collection procedure defining data collection times and the associated context of the collection also defines what information regarding the results of the collection may be viewable by a user performing the structured collection procedure on the device. In this manner, the patient can be monitored according to the structured collection procedure while preventing the patient from modifying his or her behavior based on collection results.

Collection device with selective display of test results, method and computer program product thereof

Metabolism diseases are evaluated by using a sensor to measure concentration of a medically significant analyte in a human or animal body fluid. The measurement data are correlated with the concentration of a medically significant analyte in body fluid over a time period of at least eight hours. An analytical facility analyzes time intervals within the time period to determine a stability parameter that characterizes the analyte concentration dynamics of change. The analytical facility further analyzes the stability parameters to determine disease-related particularities of metabolism.

Analytical method and investigation system

A medical appliance for use on and/or in the body of a user including a transmission unit and an activation switch connected to the transmission unit for activating the transmission unit when an activation signal is received by the activation switch. The invention encompasses systems and processes for transmitting data between a medical appliance and an external appliance, wherein, in some embodiments, the external appliance activates the medical appliance prior to data transmission when the latter is in an idle state.

Energy-optimised data transmission for a medical appliance

Sensors and a method for detecting an analyte are described. Sensors each have a volume of a hydrophilic medium that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes and a redox enzyme in contact with medium, and an electron transfer mediator. The fluid contacts sensors and at initially predetermined intervals intermittently applies a potential to electrode sufficient to oxidize the mediator and sensing current through electrode as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode. The current flow is correlated with the current flow for known concentrations of the analyte in medium.

Electrochemical sensor and method for continuous analyte monitoring

Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable to the analyte, but is impermeable to background species in the biological matrix. A refractive element is positioned in the cavity. A light source transmits light of a first intensity onto the refractive element, and a light detector receives light of a second intensity that is reflected from the cavity. A controller device optically coupled to the detector compares the first and second light intensities, and relates the intensities to analyte concentration.

Subcutaneous analyte sensor

Sensors () and a method for detecting an analyte are described. Sensors () each have a volume of a hydrophilic medium () that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes () and a redox enzyme in contact with medium (), and an electron transfer mediator. The fluid contacts sensors () and at initially predetermined intervals intermittently applies a potential to electrode () sufficient to oxidize the mediator and sensing current through electrode () as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode (). The current flow is correlated with the current flow for known concentrations of the analyte in medium ().

Small volume biosensor for continuous analyte monitoring

A fluid sampling apparatus is provided that in accordance with the present invention. The apparatus includes a housing defining a chamber, a lancet positioned in the chamber and including an end formed to create a fluid collection incision, and a light source positioned in the chamber. The light source is formed to emit a light beam of a pre-determined wavelength and for a time sufficient to seal the incision.

Fluid sampling apparatus

The invention relates to a method and a device for in vivo detection of the direction of Langer's lines in the skin. Light is irradiated into the skin as primary light at one defined site ( ) identified through the epidermis ( ) in such a way that it is transported in the skin ( ) by scattering or absorption, while part of said irradiated light emerges from the skin as secondary light in the region surrounding the irradiated site. An amplitude-dependent property of secondary light emerging from the skin ( ) around the irradiated site is measured in order to determine the preferential direction of the diffuse light transport in the skin ( ) and, consequently, determine the orientation of Langer's lines thereof.

Method and apparatus for determining the lines of optimal direction for surgical cuts in the human skin

A system ( ) for subscription monitoring of a medically significant characteristic of a bodily fluid which includes a meter ( ), a ROM circuit ( ), a test strip ( ), and a registry ( ). Meter ( ) has an identifier corresponding to a subscription user. ROM circuit ( ) is provided with test strips ( ), and contains calibration data and an identifier. The meter ( ) requires an activation code before it may conduct a biosensing test. The meter ( ) communicates with registry ( ) through communication means ( ) and provides the meter identifier and ROM circuit identifier. Registry ( ) checks for valid association of the meter identifier, ROM circuit identifier, and user identifier. If a valid association is established, the registry ( ) provides an activation code to the meter ( ), enabling meter ( ) to conduct testing during a subscription period. The meter ( ) thereafter validates the ROM circuit ( ) association on power up, so that ROM circuit ( ) may only be used with meter ( ), thereby discouraging fraudulent conveyance of ROM circuit ( ) and test strips ( ).

Subscription based monitoring system and method

An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.

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Fremont, CA, United States of America

Matthias Essenpreis