Evonik Rohm Gmbh

Biolitec Pharma Marketing Ltd

Adc Advanced Dental Care Gmbh & Co Kg

Evonik Degussa Gmbh

Matthias Epple

Hans-Ulrich Petereit

Volker Albrecht

Arno Wiehe

Rosario Lizio

Burkhard Gitter

Susanna Gräfe

Silko Grimm

Janine Schwiertz

Kathirvel Ganesan

Drazen Tadic

Gregor Doerdelmann

Gregor DÖRDELMANN

The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.

Nanoparticle

The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (pTPPP) is a preferred hydrophilic photosensitizer for photodynamic tumor therapy. In another preferred embodiment, hydrophilic cationic and anionic photosensitizers, especially those of the phenazinium, phenothiazinium and xanthenes series have been found to inactive pathogen bacteria and are the preferred photosensitizers to be formulated in calcium phosphate nanoparticle formulations for antibacterial photodynamic therapy. In another embodiment, photosensitizing nanoparticle formulations are useful to locate cells, tissues or bacteria by using fluorescence imaging methods.

Calciumphosphate-based nanoparticles as carrier-systems for photodynamic therapy

In order to provide a bone substitution material which enables mechanical stability and long-term in-vivo biocompatibility which can also be used for guided bone healing, the invention provides a method comprising the steps of providing a starting material comprising a mixture of at least a skeleton substance () and at least one functional substance, and building up a skeleton from the skeleton substance, thereby producing a profiled body (), as well as a profiled body () containing a skeleton substance () and comprising a porous structure () with pores () being interconnected with each other.

Method for producing bone substitution material

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Hattingen, Germany

Matthias Epple