Other

The Brigham and Women's Hospital, Inc.

Matthias A Hediger

Edward M Brown

Ji-Bin Peng

Yoshikatsu Kanai

The invention provides methods for regulating the transport of vitamin C across membranes.

Methods for transporting vitamin C

Methods of altering transmembrane calcium transport by altering expression of a calcium-transport protein are described.

Methods of altering calcium transport

Nucleic-acid and amino-acid sequences correspond to a calcium-transport protein regulating the movement of calcium across cell membranes.

Compositions corresponding to a calcium transporter and methods of making and using same

The present invention relates to nucleic acid and amino acid sequences corresponding to a proton-coupled peptide transporter and methods of making and using such transporter.

Compositions corresponding to a proton-coupled peptide transporter and

The present invention features an excitatory amino acid carrier protein which has high affinity for glutamate and is associated with neuronal glutamate transport, and methods of making and using the protein.

Compositions corresponding to a high-affinity glutamate transporter

An isolated nucleotide sequence encoding a urea transporter polypeptide or unique fragments of urea transporter polypeptide, is provided. One embodiment is an isolated DNA sequence (SEQ ID NO.:1) encoding a urea transporter polypeptide, that has at least two extended hydrophobic domains, each domain lacking interspersed hydrophilic domains. Also described are recombinant cells and plasmids containing the foregoing isolated DNA, preferably linked to a promoter. Isolated urea transporter polypeptide is provided, having at least two extended hydrophobic domains, each domain lacking interspersed hydrophilic domains (SEQ ID NO.:2). Portions of the foregoing isolated urea transporter polypeptides are also described. Antibodies with selective binding specificity for the polypeptides of the invention also are provided. Methods for producing urea transporter polypeptide as well as methods for testing for modulators of urea transporter polypeptide activity are also described.

Urea transporter polypeptide

A preparative gel electrophoresis apparatus comprises a first outer coolable cylinder, a second inner coolable cylinder within the outer cylinder, a compact column of separating material placed between the first and second cylinders and electrodes arranged above and below the separating column for forming an electrical field over the volume of the separating column, axially translatable adapters above and below the support, surrounding the electrodes, containing duct systems and completely surrounding the inner coolable cylinder. A method of forming the gel column by injecting gel while separating the adapters is also disclosed.

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Wellesley, MA, United States of America

Matthias A Hediger