Wisconsin Alumni Research Foundation

Matthew Woll

Samuel Helmer Gellman

Xifang Wang

Daniel H Appella

Emilie Porter

Hee-Seung Lee

Jonathan R Lai

Paul LePlae

Justin Murray

Disclosed are &#x3b2;-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the &#x3b1; and &#x3b2; carbons of the peptide backbone and &#x3b2;-polypeptides made from such monomers. Method of generating combinatorial libraries of polypeptides containing the &#x3b2;-peptide residues and libraries formed thereby are disclosed.

Beta-amino acids

Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained &#x3b3;-amino acid residue. The compounds have the formulawhere A is a hydrogen, hydroxy, amino- or carboxy-protecting group, Y is a single bond or a prolyl-containing linking group, and X and Y are &#x3b3;-amino acid residues, provided that one of X or Y is a conformationally-restrained &#x3b3;-amino acid residue, and 'a,' 'c,' and &#x201c;d&#x201d; are positive integers. The compounds find use as non-enzymatically degradable probes to mimic protein behavior in solution.

Polypeptides containing &#x3b3;-amino acids

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Madison, WI, United States of America

Matthew Woll