Nexstar Pharmaceuticals, Inc.

Gilead Sciences, Inc.

University Research Corporation

Matthew Wecker

Larry M Gold

Bruce Eaton

Kirk B Jensen

Drew Smith

Dan T Nieuwlandt

This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.

Systematic evolution of ligands by exponential enrichment: Chemi-SELEX

Systematic evolution of ligands by exponential enrichment: chemi-SELEX

Systematic evolution of ligands by exponential enrichment: chemi-selex

Methods are described for the identification and preparation of nucleic acid ligands to Substance P (SP). Included in the invention are specific RNA ligands to SP identified by the SELEX method.

High-affinity oligonucleotide ligands to the tachykinin substance P

Growing community of inventors

Boulder, CO, United States of America

Matthew Wecker