Northwestern University

Johns Hopkins University

Matthew W Rotz

Thomas J Meade

Robert J Holbrook

Martin Gilbert Pomper

Ronnie Charles Mease

Sangeeta Ray

Xing Yang

Ying Chen

Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.

Gd(III)-dithiolane gold nanoparticle conjugates

Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

Metal/radiometal-labeled PSMA inhibitors for PSMA-targeted imaging and radiotherapy

Growing community of inventors

Chicago, IL, United States of America

Matthew W Rotz