Genentech, Inc.

F. Hoffmann-la Roche Ag

Matthew W Cartwright

Andrew Madin

Bryan K Chan

Timothy Heffron

Sushant Malhotra

Emanuela Gancia

Michael Lainchbury

Craig Stivala

Jun Liang

Lewis J Gazzard

Rohan V Mendonca

Kin Chiu Fong

Yonghan Hu

John Tellis

David Favor

Andrew Good

BinQing Wei

Michael Siu

Graham Elgin Jones

Naomi S Rajapaksa

Joy Drobnick

Weiru Wang

Aihe Zhou

Binqing Wei

Aijun Lu

Blake Daniels

Baihua Hu

Malcolm Huestis

Wei Li

Po-wai Yuen

Nicholas Charles Ray

Snahel Patel

Mark Edward Zak

Simon Charles Goodacre

Richard Leonard Elliott

Terry Aaron Panchal

Yun-Xing Cheng

Toby Jonathan Blench

Terry Kellar

Elsa Amandine Dechaux

Christine Edwards

Mohammed Sajad

Naomi Rajapaksa

John C Tellis

Isoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Isoquinoline compounds and uses thereof

Naphthyridine compounds and uses thereof

Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.

Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Isoquinolines as inhibitors of HPK1

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Naphthyridines as inhibitors of HPK1

Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.

Triazolopyridine compounds, compositions and methods of use thereof

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Harlow, United Kingdom

Matthew W Cartwright