Zoetis Services LLC

Celgene Corporation

Zoetis LLC

Massachusetts Institute of Technology

Matthew W Bedore

Graham M Kyne

Richard Andrew Ewin

Michael P Curtis

Paul D Johnson

Rajendran Vairagoundar

Kevin Ronald Condroski

Natalie Anne Hawryluk

Susan M K Sheehan

Stacie S Canan

Tomasz Respondek

Sanjay Menon

Tom L McTier

Susan M Sheehan

Klavs F Jensen

Timothy F Jamison

Todd M Maddux

Mark R Cox

Nikolay Zaborenko

Imelda Hot

Christopher Scott Knauer

Christoper S Knauer

Tom L Mctier

Christopher S Knauer

Susan MK Sheehan

Defined herein are immunomodulating Formula (1) compounds stereoisomers thereof, and pharmaceutically acceptable salts thereof; wherein R, R, R, R, W, Ring C and n are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating o-het/aryl azalides

Provided herein are Heterocyclic compounds of formula I:

Heterocyclic compounds and their use for treatment of helminthic infections and diseases

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and L, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.

Endoparasitic depsipeptides

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and Lare as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.

Provided herein are Heterocyclic compounds of formula I: 

The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

Continuous flow synthesis of amino alcohols using microreactors

Growing community of inventors

Portage, MI, United States of America

Matthew W Bedore