Emd Millipore Corporation

Merck Patent Gmbh

Matthew T Stone

Mikhail Kozlov

Nanying Bian

John Paul Amara

William Cataldo

Christopher Gillespie

David Yavorsky

Joaquin A Umana

Martin Siwak

Santosh Rahane

Jie Chen

Romas Skudas

Kevin Galipeau

Wilson Moya

Ajish Potty

Jad Jaber

Michael W Phillips

Matthias Joehnck

Patricia Greenhalgh

Melissa Holstein

Damon Asher

Alex Xenopoulos

Ushma Mehta

Bianca Edelmann

Simon Braun

Matthew Turiano

Chia-Yun Sun

Kristen Cotoni

Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.

Affinity chromatography media for removal of anti-a and/or anti-b antibodies

The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.

Methods of reducing level of one or more impurities in a sample during protein purification

The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.

Selective removal of a protein from a mixture of proteins using activated carbon by adjusting solution conditions

Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

Chromatography media and method

The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.

Mixed bed ion exchange adsorber

The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.

Purification of biological molecules

Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified monoclonal IgM-A and IgM-B antibodies.

Methods of evaluating quality of a chromatography media which binds anti-A or anti-B antibodies

Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified Lectins.

Methods of evaluating quality of media suitable for removing anti-A or anti-B antibodies

The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal, of protein, fragments without adversely affecting the yield of the desired protein product.

Removal of fragments from a sample containing a target protein using activated carbon

The present invention refers to a method for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies.

Robust antibody purification

The present invention provides methods for determining whether activated carbon can be used for removing viruses or a certain virus from a sample containing a target protein.

Growing community of inventors

Arlington, MA, United States of America

Matthew T Stone