Rutgers, The State University of New Jersey

Matthew Sean Palombo

Patrick J Sinko

Xiaoping Zhang

Stanley Stein

Jieming Gao

Simi Gunaseelan

Manjeet Deshmukh

Yashveer Singh

Sherif Ibrahim

Shahriar Pooyan

The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.

Polyethylene glycol-based dendrons

This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.

Nanocarrier compositions and methods

Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis.

Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases

Growing community of inventors

Marmora, NJ, United States of America

Matthew Sean Palombo