California Institute of Technology

Talis Biomedical Corporation

Matthew S Curtis

Rustem F Ismagilov

Eugenia Khorosheva

Bing Sun

Nathan G Schoepp

Travis S Schlappi

Jesus Rodriguez Manzano

Feng Shen

Mitchell Guttman

Erik B Jue

Hedia Maamar

David A Selck

Mary Arrastia

Methods, systems and related compositions are provided to perform single-cell marking of a nucleic acid and/or protein in a sample based on in-cell or in-organelle barcoding of nucleic acid and/or protein complexes of the cell or organelle; the methods and systems herein described are configured to provide in-cell or in-organelle single-cell marked nucleic acid and/or protein complexes comprising a single-cell, cell-specific, or a single-cell organelle-specific marker.

Methods and systems for performing single cell analysis of molecules and molecular complexes

Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.

Microfluidic measurements of the response of an organism to a drug

The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.

Enhanced nucleic acid identification and detection

Disclosed herein are methods and devices for using digital isothermal amplification to detect subtle responses to environmental stimuli, such as detecting antibiotic susceptibility using digital quantification of DNA replication and/or chromosome segregation.

Digital quantification of DNA replication and/or chromosome segregation based determination of antimicrobial susceptibility

Growing community of inventors

Pasadena, CA, United States of America

Matthew S Curtis