Medtronic, Inc.

Boston Scientific Scimed, Inc.

Medtronic Vascular, Inc.

Millipede, Inc.

Medtronic Vascular Galway Limited

Matthew Rust

Randall T Lashinski

Patrick Edward Macaulay

Padraig Savage

Gianfranco Pellegrini

Finn Olavi Rinne

Richard Glenn

Terry Wayne Daniels

Michael Lee

Jack Chu

David R Erickson

Timothy R Ryan

Michael Gloss

Susheel Deshmukh

Carolyn C Majkrzak

Matthew W Weston

Jonathan Morris

Timothy D Groen

Marc A Anderson

Trevor Greenan

Michael Krivoruchko

Mike Krivoruchko

Mark Casley

Nathan K Brown

Evelyn Birmingham

Deirdre Bridget McGowan Smyth

Don H Tran

James Mitchell

Niall F Duffy

Nasser Rafiee

Jeffrey D Sandstrom

Victor Ivan Chornenky

Philip Jon Haarstad

Igor Kovalsky

Declan P Costello

Lucas Tradd Schneider

Yossi Tuval

Nareak Douk

John Gallagher

Robert H Murray

Adam Shipley

Kris Kristoffersen

Kristian Kristoffersen

Curtis Hanson

Prema Ganesan

Charles Thomas

Kenny Dwight Bruner

Frank Yang

Behrooz Nadian

Nathan Wiemeyer

Savage Padraig

Prema Ganesan O'Brien

Kshitija P Garde

Joshua Mark Inouye

Stephen Nash

Robert J Murray, Iii

Edmond Sheahan

Frank White

Kate Corish

Graham Krumpelmann

Ronan Rogers

Leonel Mendoza

Vance E Swanson

Jia Hua Xiao

William Steinberg

James Machek

Eunsung Park

Heath Muzslay

Damian Carr

Zirao Zheng

Patrick MacAulay

Sonny Yamasaki

Christopher Robert Lashinski

Levi Wolterstorff

Robert Murry, Iii

Jonathon Morris

James Kearns

Leonal Mendoza

Robert Murray Iii

Dave R Erickson

Nathan Wiiemeyer

Tossi Tuval

Matthew Weston

Stella Kim

Declan Costello

Niall Duffy

A delivery system for use with a prosthetic heart valve having a stent frame to which a valve structure is attached, includes a shaft assembly including a distal end and a coupling structure disposed near the distal end and configured to be coupled to a distal end of the prosthetic heart valve. The system includes a sheath assembly defining a lumen sized to slidably receive the shaft assembly. The delivery system is configured to transition from a loaded state in which the sheath assembly encompasses the prosthetic heart valve to a deployed state in which the sheath assembly is withdrawn from the prosthetic heart valve. The coupling structure is configured to provide a controlled expansion or contraction of the distal end of the prosthetic heart valve based on longitudinal movement of the distal end of the shaft assembly.

Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve

A prosthetic valve including a wire frame having a generally tubular body portion, an interior area, a longitudinal axis, a first end comprising a plurality of crowns, and a second end comprising a greater number of crowns than the first end. The wire frame includes a plurality of adjacent rows of modified diamond-shaped structures extending between the first and second ends. The prosthetic valve further includes a valve structure that includes a plurality of leaflets and that is attached within the interior area of the wire frame.

Stents for prosthetic heart valves

A polymer coating/ring is employed to aid in the sealing and connection of modular elements used in body flow lumens for the exclusion and bypass of diseased regions of the flow lumen, such as where aneurysm occurs adjacent to branching blood vessels.

Methods and apparatus for treatment of aneurysms adjacent branch arteries

Excessive dilation of the annulus of a mitral valve may lead to regurgitation of blood during ventricular contraction. This regurgitation may lead to a reduction in cardiac output. Disclosed are systems and methods relating to an implant configured for reshaping a mitral valve. The implant comprises a plurality of struts with anchors for tissue engagement. The implant is compressible to a first, reduced diameter for transluminal navigation and delivery to the left atrium of a heart. The implant may then expand to a second, enlarged diameter to embed its anchors to the tissue surrounding and/or including the mitral valve. The implant may then contract to a third, intermediate diameter, pulling the tissue radially inwardly, thereby reducing the mitral valve and lessening any of the associated symptoms including mitral regurgitation.

Adjustable endolumenal implant for reshaping the mitral valve annulus

An anchor assembly having a helical anchor extending through an anchor bore defined in the anchor housing. In some embodiments, at least one helical turn of the helical anchor extends beyond a portion of the anchor bore. In some embodiments, at least one helical turn of the helical anchor extends beyond a side wall of the anchor housing. In some embodiments, the helical turns of the helical anchors of anchor assemblies mounted adjacent one another on an implantable device nest within one another when the implantable device is in an unexpanded configuration. In some embodiments, the distalmost helical turn of the helical anchor has an outer diameter greater than more proximal helical turns of the helical anchor. In some embodiments, the outer diameters of the at least some of the helical turns of the helical anchor taper from a distal end to a proximal end of the helical anchor.

Anchoring devices, systems, and methods for implantable device

Solutions for reducing irritation and/or trauma which may result upon contact of an implanted implantable device with tissue surrounding or adjacent to the implantable device. Various embodiments include features which allow a tangential or otherwise atraumatic contact of the implantable device with the tissue, in contrast with a sharper contact which may occur with prior art implantable devices. The broad principles are applicable to annuloplasty devices, and have other broader applications as well.

Atraumatic components and structures for implantable devices

Features for a heart valve device are described. The device may include a frame with anchors configured to secure the device to tissue. The frame may include a flared end or skirt for additional securement of the implanted device. The device may include a seal such as a barrier and/or cuff for preventing leakage. The device may contract for endovascular delivery of the device to the heart and expand for securement within the heart, such as the within the native mitral valve annulus. The device may include a replacement valve. The valve may have leaflets configured to re-direct blood flow along a primary flow axis.

Valve replacement using moveable restraints and angled struts

A system includes a medical device for implanting in a valve of a subject, the implantable medical device having a self-expanding frame; and a holder configured to retain the frame of the implantable medical device in a constricted configuration and to control expansion of the frame. The holder has a controllably constrictable and expandable loop, wherein the loop is disposed about at least a portion of the self-expanding frame such that constriction or expansion of the first loop controls constriction or expansion of the frame.

Valve delivery tool

Systems, devices and methods related to various heart valve implants and for delivery of those heart valve implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. Anchors secure the implant to tissue and collars are used to decrease the angle between the struts and contract the frame. The implant thus expands from a first size inside of a delivery catheter, to a second and larger deployed size inside the heart to engage and anchor with the tissue, and then to a third and contracted size to re-size the annulus and/or provide a secure fit for a replacement heart valve. Various delivery systems including imaging capabilities for precise delivery, positioning and anchoring of the various implants are further described.

Implantable device and delivery system for reshaping a heart valve annulus

Features for a restraint to facilitate delivery and deployment of an implantable cardiac device are described. The restraint may include a series of circumferential engagements for securing inwardly corresponding portions of the implant. The restraint may be located inside the implant and provide a radially inward force on the implant. The restraint may include a center shaft having a series of grooves configured to cooperate with corresponding splines of the implant. Distal or proximal advance of the restraint disengages the restraint from the implant. The implant may include a tubular frame configured to contract and be secured by the restraint in a contracted configuration and to expand upon disengagement from the restraint. The restraint may provide for a smaller overall cross-sectional profile of a transcatheter delivery system, for instance by negating the need for a distal delivery sheath.

Delivery system with integrated central restraint for an implantable cardiac device

Systems, devices and methods related to various heart valve implants and for delivery of those implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. The implant is secured to tissue with anchors that can rotate without axial advancement to engage tissue while drawing the implant closer to the tissue. Collars are used to decrease the angle between struts of a frame to contract the implant. The implants can include a rotatable shaft, such as a threaded shaft, located internally to an axially translatable collar. Rotation of the shaft transmits force to the collar to cause the collar to translate axially, closing the angle of adjacent struts and decreasing the width of the implant and thus of the annulus. The implants can be delivered, secured and contracted via a catheter. The implants are repositionable and retrievable via catheter.

Methods related to delivery of various heart valve implants are described. The implant may be delivered using an ultrasound imaging delivery system. The ultrasound imaging delivery system may be used to deliver a variety of different devices, including mitral valve reshaping devices, mitral valve replacement valves, and others. A deployment catheter carrying an implant having a tissue anchor is advanced to a deployment site in a heart. An imaging element is positioned adjacent the implant and a relationship between the tissue anchor and an anatomical landmark in the heart is visualized. The implant is then attached by driving the tissue anchor into tissue in the heart.

Methods for delivery of heart valve devices using intravascular ultrasound imaging

Growing community of inventors

Windsor, CA, United States of America

Matthew Rust