Merck Sharp + Dohme Corp.

Schering Corporation

Matthew Richards

Gerald Wayne Shipps, Jr

Cliff C Cheng

Xiaohua Huang

M Arshad Siddiqui

Thierry Olivier Fischmann

Binyuan Sun

Jose S Duca

Hongbo Zeng

Panduranga Adulla Reddy

Timothy J Guzi

Lianyun Zhao

Shuyi Tang

Praveen K Tadikonda

Tzu Tshin Wong

Michael P Dwyer

Yongqi Deng

Kartik M Keertikar

Andrew J McRiner

Marc A Labroli

Zhaoyang Meng

Luis E Torres

Mehul F Patel

Iwona Wrona

Duan Liu

Yang Nan

Amit K Mandal

Cory S Poker

Yinyan Zhao

Brian M Eklov

Andrew Mcriner

Iwona E Wrona

Marc M Labroli

Cory Poker

The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. 

Anilinopiperazine derivatives and methods of use thereof

The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors

The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

Thiazole carboxamide derivatives and their use to treat cancer

The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. 

2-aminothiazole-4-carboxylic amides as protein kinase inhibitors

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Somerville, MA, United States of America

Matthew Richards