E.i. Dupont De Nemours and Company

Basf Se Corporation

Bristol-myers Squibb Compnay

Corteva Agriscience LLC

Kocide LLC

Matthew Richard Oberholzer

Rafael Shapiro

Brian Michael Green

Patricia Andres

Jennifer Leigh Nelson

Stephen Craig Fields

Samir Kulkarni

Robert J Pasteris

Albert Loren Casalnuovo

Sigridur Soley Kristjansdottir

Bang-Chi Chen

Mary Ann Hanagan

Erin Demko

Jun Yan

Boguslaw Mudryk

Nicolas Cuniere

Huiping Zhang

Lucius Rossano

Ty Wagerle

Rachel Melissa Witek

Nadejda Pavlova

Robert James Pasteris

Methods for preparing crystalline L-glufosinate ammonium monohydrate are disclosed. The methods include forming a mixture comprising water, a water-miscible organic solvent, ammonium hydroxide, and a glufosinate starting material containing L-glufosinate ammonium and D-glufosinate ammonium. L-Glufosinate ammonium monohydrate is crystallized and separated from the mixture, providing L-glufosinate ammonium monohydrate Form B. Compositions and methods employing the crystalline L-glufosinate ammonium monohydrate are also described.

Methods for producing crystalline L-glufosinate ammonium monohydrate

Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are described.

Methods for the purification of L-glufosinate

The present invention provides a method for preparing a compound of Formula C, Formula D, or Formula F: wherein each R, R, and Ris independently H, SFs, N(C-Calkyl)(C-Calkyl), C(═S)N(C-Calkyl)(C-Calkyl), SON(C-Calkyl)(C-Calkyl), OSO(C-Calkyl), OSON(C-Calkyl)(C-Calkyl), N(C-Calkyl)SO(C-Calkyl), or C-Calkyl, C-Chaloalkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, C-Chalocycloalkyl, C-Calkylcycloalkyl, C-Ccycloalkylalkyl, C-Ccycloalkylcycloalkyl, C-Calkylcycloalkylalkyl, C-Ccycloalkenyl, C-Calkoxy, C-Chaloalkoxy, C-Ccycloalkoxy, C-Chalocycloalkoxy, C-Ccycloalkylalkoxy, C-Calkenyloxy, C-Calkynyloxy, C-Calkylthio, C-Calkylsulfinyl, C-Calkylsulfonyl, C-Ccycloalkylthio, C-Ccycloalkylsulfinyl, C-Ccycloalkylsulfonyl, C-Ccycloalkylalkylthio, C-Ccycloalkylalkylsulfinyl, C-Ccycloalkylalkylsulfonyl, C-Calkenylthio, C-Calkenylsulfinyl, C-Calkenylsulfonyl, C-Calkynylthio, C-Calkynylsulfinyl, C-Calkynylsulfonyl, or phenyl; or two of R, R, and Ron adjacent ring atoms may be taken together to form a 5-to 7-membered carbocyclic or heterocyclic ring, each ring containing ring members selected from carbon atoms and up to 3 heteroatoms independently selected from up to 2 O, up to 2 S, and up to 3 N, wherein up to 2 carbon atom ring members are independently selected from C(═O) and C(═S) and such ring is optionally substituted with up to 3 substituents independently selected from the group consisting of C-Calkyl, C-Chaloalkyl, C-Calkenyl, C-Chaloalkenyl, C-Calkynyl, C-Chaloalkynyl, C-Ccycloalkyl, C-Chalocycloalkyl, C-Calkylcycloalkyl, C-Chaloalkylcycloalkyl, C-Ccycloalkylalkyl, C-Chalocycloalkylalkyl, C-Calkoxy, C-Chaloalkoxy, C-Calkoxycarbonyl, C-Chaloalkoxycarbonyl, C-Calkylcarbonyl and C-Chaloalkylcarbonyl; and M is an inorganic cation or organic cation.

Process and intermediates for the preparation of certain nematicidal sulfonamides

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

The present invention provides a method for preparing a compound of Formula C, Formula D, or Formula F: 

Disclosed are solid forms of 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. Disclosed are compositions for protecting a plant or plant seed from diseases caused by fungal pathogens comprising a biologically effective amount of a solid form of Compound 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid carriers. Compositions comprising a mixture of a solid form of Compound 1 and at least one other nematocide, insecticide and/or fungicide are also disclosed. Also disclosed are methods for protecting a plant or plant seed from diseases caused by fungal pathogens comprising applying to a plant or seed, or to the environment of the plant or seed, a biologically effective amount of a solid form of Compound 1.

Solid forms of fungicidal pyrazoles

A method for preparing a compound of Formula 1 comprising contacting a compound of Formulae 2 and 3 in the presence of a palladium source, a ligand, a base and carbon monoxide wherein R, R, X and Rare as defined in the disclosure. A method for preparing a compound of Formula 5 wherein R, R, R, R, R, Rand Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing a compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method above. 

Method for preparing 2-aminobenzamide derivatives

Disclosed are solid forms of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazoyl]-2 -thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifuoromethyl)-1H-pyrazol-1-yl]ethanone (Compound 1). Also disclosed are methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another form. Further disclosed are methods for controlling plant diseases caused by fungal plant pathogens comprising applying to a plant or portion thereof, or to a plant seed, a fungicidally effective amount of a solid form of Compound 1. Additionally disclosed are fungicidal compositions comprising a fungicidally effective amount of a solid form of Compound 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid carriers and also compositions comprising a mixture of a solid form of Compound 1 and at least one other fungicide or insecticide.

Solid forms of an azocyclic amide

Disclosed are solid forms of 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (Compound 1). Methods for the preparation of solid forms of Compound 1 and for the conversion of one solid form of Compound 1 into another are disclosed. Disclosed are fungicidal compositions comprising a fungicidally effective amount of a solid form of Compound 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid carriers. Compositions comprising a mixture of a solid form of Compound 1 and at least one other fungicide or insecticide are also disclosed. Also disclosed are methods for controlling plant diseases caused by fungal plant pathogens comprising applying to a plant or portion thereof, or to a plant seed, a fungicidally effective amount of a solid form of Compound 1.

A method is disclosed for preparing a non-hydratable crystal form from a hydratable crystal form of 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1H-pyrazole-5-carboxamide (Compound 1). 

Method for preparing a non-hydratable crystal form

Disclosed is a method of stabilizing copper(II) hydroxide, the method comprising the sequential steps of: (a) combining copper(II) hydroxide, a water-soluble phosphate and water to form a mixture; and (b) drying the mixture. Also disclosed is stabilized copper(II) hydroxide prepared according to said method and a composition comprising stabilized copper(II) hydroxide prepared according to said method and at least one of a surfactant, a solid diluent or a liquid diluent.

Method for stabilizing copper hydroxide

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.

Growing community of inventors

Wilmington, DE, United States of America

Matthew Richard Oberholzer