Cytiva Sweden Ab

Merck Sharp + Dohme Corp.

Matthew Rainka

Patrick Joseph McCloskey

Matthew Jeremiah Misner

Hongyi Zhou

David Moore

Ronald J Doll

Brian Alexander McKittrick

Sunil Paliwal

Thierry Olivier Fischmann

Hon-Chung Tsui

Angela Dawn Kerekes

Mary Ann Caplen

Hyunjin M Kim

Sara Esposite

Ang Li

Multicomponent copolymers including two or more types of repeat units is presented. In one example, the multicomponent copolymer includes at least one repeat unit AC having a structure (I), at least one repeat unit DC having a structure (II), and at least one repeat unit BC having a structure (III) or (V). The multicomponent copolymer may be cross-linked via a cross-linking agent. A polymer blend including the multicomponent copolymer or a cross-linked copolymer and a second polymer is also provided. The multicomponent copolymer may be a random or a block copolymer. The structural units of the multicomponent copolymers provide improved, tunable properties, such as improved biocompatibility and hydrophilicity, protein fouling, and mechanical properties, to the copolymers and/or the membranes fabricated from the copolymers.

Zwitterion-functionalized multicomponent copolymers and associated polymer blends and membranes

The present invention provide Imidazole Carboxamide Compounds of Formula (I): wherein D, T, R, R, R, and Rare as defined herein, and pharmaceutically acceptable salts of such Imidazole Carboxamide Compounds. The Imidazole Carboxamide Compounds are useful in the treatment of cancer and other aberrant conditions that result from overstimulation of the PDK-1 signaling pathway. 

N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1

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Schenectady, NY, United States of America

Matthew Rainka