Exelixis, Inc.

Genentech, Inc.

Cytokinetics, Inc.

Matthew Pfeiffer

Sriram Naganathan

C Gregory Sowell

Nathan Guz

Jason Yang

Tracy Bostick

Neel Kumar Anand

Bradley Paul Morgan

Qi Gao

Amit Srivastava

Jo Ann Wilson

Denise Andersen

Neil G Andersen

Norma Tom

Provided herein is a process for the preparation of (R)—N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide, intermediates thereof, and salts of the foregoing.

Process for preparing aficamten

Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Process for making compounds for use in the treatment of cancer

A process for preparing a compound of Formula I is disclosed, comprising the steps: wherein: and a tertiary amine base to the mixture of step (a) to form a compound of Formula A; and  

Process for preparing quinoline derivatives

A process for preparing a compound of Formula I is disclosed: wherein: and a tertiary amine base to the mixture of step (a) to form a compound of Formula A; and  

Growing community of inventors

Salt Lake City, UT, United States of America

Matthew Pfeiffer