Vertex Pharmaceuticals, Inc.

Matthew Paul Grote

Jean-Damien Charrier

Steven John Durrant

David Kay

Joanne Louise Pinder

Dennis James Hurley

Hayley Marie Binch

Pierre-Henri Storck

Michael Edward O'Donnell

Pramod Virupax Joshi

Thomas Cleveland

Philip Michael Reaper

Lev Tyler Dewey Fanning

Anisa Nizarali Virani

Ronald Marcellus Alphonsus Knegtel

Stephen Clinton Young

The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Compounds useful as inhibitors of ATR kinase

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New York, NY, United States of America

Matthew Paul Grote