The University of Akron

Matthew Panzner

Wiley Jay Youngs

Claire A Tessier

Carolyn L Cannon

Carol A Quezada

Abdulkareem Melaiye

Jered C Garrison

Michael Deblock

Brian Wright

Patrick Wagers

Nikki Robishaw

Semih Durmus

Jered Garrison

Kascatan-Nebioglu Aysegul

Singly and multiply charged imidazolium cations (ICs) have been identified as a class of chemical compositions that possess potent antineoplastic, antibacterial and antimicrobial properties. The imidazolium cations disclosed demonstrate greater or equivalent potency towards cancerous cells as the current clinical standard, cisplatin. These imidazolium cations, however, achieve this efficacy without any of the known toxic side effects caused by heavy metal-based antineoplastic drugs such as cisplatin.

Azolium and purinium salt anticancer and antimicrobial agents

The present invention generally relates to metal complexes of N-heterocyclic carbenes that contain one or more additional active moieties and/or groups therein. In one embodiment, the present invention relates to metal complexes of N-heterocyclic carbenes that contain an anti-fungal and/or anti-microbial moiety and/or group in combination with one or more additional active moieties and/or groups selected from fluoroquinolone compounds or derivatives thereof; steroids or derivatives thereof; anti-inflammatory compounds or derivatives thereof; anti-fungal compounds or derivatives thereof; anti-bacterial compounds or derivatives thereof; antagonist compounds or derivatives thereof; Hreceptor compounds or derivatives thereof; chemotherapy compounds or derivatives thereof; tumor suppressor compounds or derivatives thereof; or Cto Calkyl heteroatom groups where the heterotatom is selected from S, O, or N. In still another embodiment, the present invention relates to metal complexes of N-heterocyclic carbenes that contain an anti-fungal and/or anti-microbial moiety and/or group in combination with two or more additional active moieties and/or groups selected from fluoroquinolone compounds or derivatives thereof; steroids or derivatives thereof; anti-inflammatory compounds or derivatives thereof; anti-fungal compounds or derivatives thereof; anti-bacterial compounds or derivatives thereof; antagonist compounds or derivatives thereof; Hreceptor compounds or derivatives thereof; chemotherapy compounds or derivatives thereof; tumor suppressor compounds or derivatives thereof; or Cto Calkyl heteroatom groups where the heterotatom is selected from S, O, or N.

Metal complexes of N-heterocyclic carbenes

A method for inhibiting microbial growth comprises administering an effective amount of a silver complex of a N-heterocyclic amine. A method for treating cancer cells or a method for imaging one or more tissues of a patient includes administering an effective amount of a complex of a N-heterocyclic amine and a radioactive metal. A method for treating urinary tract infections utilizing silver complexes of N-heterocyclic carbenes. N-heterocyclic carbenes of the present invention may be represented by the formula wherein Z is a heterocyclic group, and Rand Rare, independently or in combination, hydrogen or a C-Corganic group selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heterocyclic, and alkoxy groups and substituted derivatives thereof.

Metal complexes of N-heterocyclic carbenes as antibiotics

N-heterocyclic functionalized polymers and methods of use in fuel cells. Phenoxy-substituted polyphosphazenes and phosphazene trimers functionalized with azoles can provide polymer electrolyte membranes with high thermal stability coupled with a large number of proton binding sites per monomer unit.

Electrolyte membranes and methods of use

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Akron, OH, United States of America

Matthew Panzner