The Automation Partnership (cambridge) Limited

The Automation Partnership Ltd.

Matthew Paley

Richard Wales

Andrew Tait

A reversible liquid filtration system for cell culture perfusion comprises: a bioreactor vessel (B), for storing the cell culture (L); a perfusion pump (P), comprising a reciprocable element (P) which is movable in opposing first and second pumping directions (dF, dR); a filter (F); and first and second bi-directional valves (BV, BV), each selectively controllable between open and closed positions. The perfusion pump (P), the filter (F), and the first and second bi-directional valves (BV, BV), together comprise a fluidic circuit in communication with the bioreactor vessel (B). The bi-directional valves (BV, BV) are controllable to open and close in co-ordination with the reciprocating perfusion pump (P), in order to enable both a two-way filtering flow around the fluidic circuit and also an alternating filtering flow between the bioreactor vessel (B) and the perfusion pump (P).

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Cambridge, United Kingdom

Matthew Paley