Tokitae LLC

General Electric Company

Matthew P Horning

Benjamin K Wilson

Michael C Hegg

Matthew R Behrend

Lowell L Wood, Jr

Clarence T Tegreene

Jordin T Kare

Nathan P Myhrvold

Courosh Mehanian

Kevin Paul Flood Nichols

David Joseph Gasperino

Liming Hu

Charles Delahunt

Shawn McGuire

Clay Matthew Thompson

Cary Richard Champlin

Victor Petrovich Ostroverkhov

Ralf Lenigk

Mark Marshall Meyers

Ozgur Emek Yildirim

Phillip Rutschman

Timothy Toepfer

Keith Michael Looney

Terry Lee Saunders

Daniel Keith Connors

Phil Rutschman

Kevin P F Nichols

David Gasperino

Techniques and technologies for automated microscopy scanning systems are disclosed wherein a microscopy system performs 'hunt mode' operations at coarsely-spaced locations throughout a scanning window until an acceptable quality scan result is achieved. The system then performs detailed scans at all fields of view within a grid cell that includes the location having the acceptable scan result. The system performs another evaluation of the scan results for the entire grid cell, and if the scan results for the grid cell are collectively acceptable, then the system proceeds to perform 'scan mode' operations. The scan mode operations include scanning and evaluating all of the fields of view within one or more grid cells adjacent to the acceptable grid cell from the hunt mode operations. The system may successively perform hunt mode operations and scan mode operations, compiling information regarding one or more aspects of the scanning process, until one or more termination criteria are satisfied.

Automated microscopy scanning systems and methods

Disclosed is a low-cost, portable photo thermal spectroscopy (PTS) reader for use in detecting the presence of diseases in the bodily fluid of affected patients. The PTS reader is designed to be durable, easy to use and provide readings from the Lateral Flow Assay (LFA) with rapid results. Also provided are methods of use.

Fixed optics photo-thermal spectroscopy reader and method of use

Embodiments disclosed herein are directed to a photothermal spectroscopy assay reader including a light source configured to emit light in the red range of the light spectrum. Methods of operating such photothermal spectroscopy assay readers are also disclosed. Assay kits including a lateral flow assay and a photothermal spectroscopy assay reader configured to read the photothermal spectroscopy assay reader are also disclosed.

Photothermal spectroscopy assay readers, and related assay kits and methods

Embodiments disclosed herein are directed to systems and methods for determining a presence and an amount of an analyte in a biological sample. The systems and methods for determining the presence of an analyte utilize a plurality of images of a sample slide including multiple fields-of-view having multiple focal planes therein. The systems and methods utilize algorithms configured to balance the color and grayscale intensity of the plurality of images and based thereon determine if the plurality of images contain the analyte therein.

Image analysis systems and related methods

Embodiments disclosed herein are directed to systems and methods for determining a presence and an amount of an analyte in a biological sample. The systems and methods for determining the presence of an analyte utilize a plurality of images of a sample slide including multiple fields-of-view having multiple focal planes therein. The systems and methods utilize algorithms configured to color and grayscale intensity balance the plurality of images and based thereon determine if the plurality of images contain the analyte therein.

Embodiments disclosed herein are directed to photothermal spectroscopy apparatuses and systems for offset synchronous testing of flow assays. Methods of using and operating such photothermal spectroscopy systems are also disclosed.

Photothermal spectroscopy systems for offset synchronous testing of flow assays and methods of using same

Systems, devices, and methods are described for providing a monitor or treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.

Systems, devices, and methods for detection of malaria

Devices and methods for preparing and assessing a liquid sample are described which include: a microfluidic microscopy device including an absorbent structure including at least one dry dye for a liquid and configured to convey a polar liquid from a first end of the absorbent structure through the at least one dry dye for a liquid to a second end of the absorbent structure, a support structure positioned adjacent to a first surface of the absorbent structure, a lid structure positioned adjacent to a second surface of the absorbent structure, and a clamping structure positioned to maintain a relative position of the support structure and the lid structure to form a tapered internal chamber adjacent to the second end of the absorbent structure.

Devices and methods for staining and microscopy

Systems, devices, and methods are described that modulate a specimen-background dark-field micrograph contrast.

Systems, devices, and methods including a dark-field reflected-illumination apparatus

Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.

Systems, devices, and methods including paramagnetic oscillation, rotation and translation of hemozoin asymmetric nanoparticles in response to multi-harmonic optical detection of the presence of hemozoin

Growing community of inventors

Seattle, WA, United States of America

Matthew P Horning