Mayo Foundation for Medical Education and Research

Other

Matthew P Goetz

Liewei Wang

Judy C Boughey

Richard M Weinshilboum

Matthew M Ames

Jia Yu

Ping Chen

Liyi Geng

Yang Gao

William S Brimijoin

Bo Qin

James N Ingle

Krishna R Kalari

Vera J Suman

Fergus J Couch

This document provides methods and materials for using butyrylcholinesterases (BChE) to treat cancer (e.g., triple negative breast cancer or prostate cancer). For example, methods and materials for using nucleic acid vectors (e.g., viral vectors) to express BChE polypeptides under conditions that reduce the number of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) and/or reduce the growth rate of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) are provided.

Methods and materials for using butyrylcholinesterases to treat cancer

This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of USP7 polypeptide to increase the sensitivity of cancer cells (e.g., CD340cancer cells such as HER2cancer cells) to treatment with an inhibitor of a CD340 polypeptide (e.g., an inhibitor of a HER2 polypeptide) are provided. Methods and materials for using USP7 polypeptide inhibitors in combination with CD340 polypeptide inhibitors to treat cancer (e.g., HER2breast cancer that was refractory to trastuzumab alone treatment) are provided.

Methods and materials for treating cancer

A water level control system and device is provided which maintains a desired running level of water in a surge tank connected to a pool or other body of water by facilitating automatic drainage of precipitation water from the body of water. The water level control system includes a water level control device configured to open and close a drain in the surge tank. The water level control device can adopt an open position when water in the surge tank is at a first level slightly above the running level, and a closed position in the presence of surge water or water displaced by bathers causing a rapid water rise in the surge tank above first level.

Water level control device for draining rain water from a pool installation

This document provides methods and materials involved in assessing chemotherapy responsiveness and treating cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) is likely to respond to chemotherapy (e.g., a taxane therapy) based at least in part on the presence of a variant in the mammal's polycystic kidney disease gene 1 (PKD1) are provided. In addition, methods and materials involved in treating mammals having cancer (e.g., breast cancer) by administering an inhibitor of ubiquitin specific peptidase 2 (USP2) polypeptide activity (e.g., NSC-632839, a 2-cyano-pyrimidine, or a 2-cyano-triazine) in combination with another chemotherapeutic agent such as a taxane therapy are provided.

Methods and materials for assessing chemotherapy responsiveness and treating cancer

Growing community of inventors

Rochester, MN, United States of America

Matthew P Goetz