Anacor Pharmaceuticals, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Research Triangle Institute

Matthew Orr

Jacob J Plattner

Robert Toms Jacobs

Daitao Chen

Scott P Runyon

John A Kepler

Hernan A Navarro

Michael A Rogawski

Rafal Kaminski

Edgar Cook

Jessica Sligar

Yong-Kang Zhang

Vincent S Hernandez

Huchen Zhou

Dazhong Ding

Long Yi

Stephen Wring

Yiqing Feng

Hernan Navarro

Edgar (deceased) Cook

John Kepler

Cook Edgar

This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Boron-containing small molecules as antiprotozoal agents

This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage. 

Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties

Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties

Boron-containing small molecules as anti-protozoal agents

This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent. The exemplary compounds have the following formula: wherein X is selected from the group consisting of substituted phenyl, substituted or unsubstituted heteroaryl and unsubstituted cycloalkyl; Ris selected from the group consisting of H, unsubstituted Cor Cor Cor Cor Cor Calkyl and unsubstituted Cor Cor Cor Ccycloalkyl; Ris selected from the group consisting of H, unsubstituted Cor Cor Cor Cor Cor Calkyl and unsubstituted Cor Cor Cor Ccycloalkyl;with the proviso that Rand R, along with the atom to which they are attached, are optionally joined to form a 3 or 4 or 5 or 6 membered ring, with the proviso that Rand Rcannot both be H, or a salt thereof.

Boron containing small molecules as antiprotozoal agents

Boron-containing small molecules as anti-protozoal agent

This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.

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Raleigh, NC, United States of America

Matthew Orr