London Health Sciences Centre Research Inc.

Matthew Olding Hebb

Susanne Schmid

Eugene Wong

Terry Peters

Erin Iredale

Methods, systems and non-transitory computer readable storage media of electric field treatment planning of a target tissue. A method of electric field treatment planning of a target tissue site includes: (a) obtaining an image of the target tissue site, (b) determining volume and one or more electric properties of the target tissue site, (c) using the volume and the one or more electric properties to: (i) determine a number of electrodes to treat the target tissue site with electric fields, each electrode having one or more contacts, (ii) determine a placement of the number of electrodes within the target tissue site, and (iii) relative to one of the contacts in one of the number of electrodes at the placement determined in (ii), determine an electric field that results in a prescribed electric field coverage of the target tissue site.

Planning and delivery of dynamically oriented electric field for biomedical applications

The present invention relates to a method of producing expandable cultured brain cells. The brain cells are neurotrophic factor (NTF) positive. The expandable cultured brain cells are obtained by culturing a biopsy obtained from the cortical and/or subcortical brain region of a living subject. The biopsies can be obtained during neurosurgical procedures such as deep brain stimulation. The expandable cultured brain cells of the present invention are useful for the treatment of neurological diseases and other medical conditions.

Expandable cell populations from brain biopsies of living subjects

An intratumoral modulation therapy (IMT) method for the treatment of nervous system and systemic tumor in a patient which includes: (a) chronically implanting an electrode adjacent to or in the tumor of the patient or in a residual tumor bed, the electrode having electrical leads connected thereto; and (b) generating electric stimulation and applying the electric stimulation through the electrical leads to the electrode adjacent to or within the tumor. A method of transferring genetic material to a tumor cell which includes: (a) positioning an electrode adjacent to the tumor cell, the electrode having electrical leads connected thereto; (b) generating electric stimulation and applying the electric stimulation through the electrical leads to the electrode adjacent the cancer cell; and (c) delivering the genetic material to the tumor cell treated with the continuous alternating electric stimulation.

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London, Canada

Matthew Olding Hebb