Millennium Pharmaceuticals Limited

Matthew O Duffey

Steven P Langston

Tricia J Vos

He Xu

Hirotake Mizutani

Dylan Bradley England

Zhigen Hu

Charles McIntyre

Koji Ono

Dominic J Reynolds

Francois Soucy

Gang Li

Amy M Elder

Indu T Bharathan

Brian Scott Freeze

Jianping Guo

Charles Mcintyre

Robert Downham

Mitsuhiro Ito

Alexandra E Gould

Paul D Greenspan

Christelle C Renou

Ruth S Adams

Scott Freeze

Bheemashankar A Kulkarni

Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, R, R', R, R, X, X, X, R, Z, and Zhave the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Heteroaryl compounds useful as inhibitors of SUMO activating enzyme

Heteroaryl compounds useful as inhibitors of sumo activating enzyme

Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, R, R, R, R, X, X, X, R, Z, and Zhave the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, R, R, R, R, X, R, R, R, R, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders. 

Heteroaryl inhibitors of sumo activating enzyme

This invention provides thiophene compounds of formula I: 

Thiophenes and uses thereof

This invention provides compounds of formula I: 

Thiolactams and uses thereof

The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.

Certain pyrazoline derivatives with kinase inhibitory activity

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Chicago, IL, United States of America

Matthew O Duffey